Establishment of Drug Safety Performance Evaluation Indicator System for Work Quality Evaluation of Drug Administration Department / 中国药房

OBJECTIVE:To establish drug safety performance indicator system in Beijing,and to provide reference for evaluat-ing work quality of administration department and drug market safety reasonably. METHODS:Through literature survey,expert brainstorming and maximum difference scaling,the indicators of drug safety performance evaluation system in Beijing were select-ed,and internet questionnaire survey was conducted among 20 regulators by using SSI Web software. The weight of each indicator was analyzed. RESULTS & CONCLUSIONS:4 factors of drug safety performance have been selected involving 27 indicators,ig. Results of drug sampling test(Oc)which reflect drug market safety directly;results of special drug sampling test(So)which mea-sure the quality of essential medicine;drug sampling operation standard (Na) which measure the completion of drug sampling by procedure or plan;rationality of drug sampling (Ra) which guarantee the rationality of sampling procedure and representativeness of sampled drugs. Finally,20 indicators are identified by experts. The weight of 4 factors are 21%,14%,40% and 25%,respec-tively. Established drug safety performance evaluation system can achieve quantitative check of drug supervision departments,and dispose several problems as rely on subjective factor greatly,lack of objective and uniform standard,only check the results. It pro-vides reference for the formulation of drug safety performance evaluation indicators in other provinces,cities and municipalities.

Circannual rhythms of parathyroid hormone-related protein in growing rats after functional mandibular protrusion / 实用口腔医学杂志

Objective:To investigate the levels of parathyroid hormo ne -related protein(PTHrP) in mandibular condylar cartilage during mandible forwar d positioning in different seasons. Methods:64 SD rats were rand omly divided into four groups according to seasons. Orthodontic appliance was us ed in 32 rats for 12 hours each day in daytime for mandibular protrusion. 8 rats were sacrificed at each season time point.Condyle samples were processed for PT HrP detection by a two-site immunoradiometric assay (IRMA) method.Another 32 ra ts without treatment were used as the controls.Macroscopic and microscopic appro ach were applied to analyze the results. Results:The level of P THrP in mandibular condylar cartilage(MCC) in the group of orthodontic treatmen t was higher than that in the control group(P